Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.

In the subanalyses, subjects whoever lovers made use of condoms completely of the time was basically divided into a couple groups on such basis as the solutions so you can issue “Performed the lover’s knob actually touch the hole of your vagina instead a condom?” If the sufferers constantly responded “no” each work of vaginal sex inside the eight-month period, they were coded because the having got “no genital contact versus an effective condom.” Analyses was indeed performed given that revealed more than, having four types of the fresh new regularity out of condom have fun with (100 % without any genital contact instead a great condom, 100 percent with otherwise an unfamiliar frequency out-of vaginal get in touch with as opposed to an excellent condom, and you may about three groups less than completely, because discussed more than).

Furthermore, Cox proportional-risks designs were utilized to decide exposure circumstances to your recognition of event cervical squamous intraepithelial lesions within the seven months ahead of certain Pap take to (on such basis as a past observance that most sores can be found after event problems 23 ). An excellent 51-day lag before every visit are provided due to the fact 51 weeks was this new quickest noticed period amongst the day a lady first had sex and day off detection out of an instance lesion in the this study. Data getting such victims was basically censored adopting the very first identification out-of a case lesion.

Results

The new imply (±SD) age the fresh 82 subjects at the enrollment was 19.3±0.eight age. The fresh new sufferers done 709 check outs. The fresh suggest pursue-upwards big date is actually 33.9±11.8 days, the brand new imply level of check outs per girl is 8.6±dos.nine, and average time taken between visits are 4.1 days. Log studies have been 90.7 percent done, and you can condom research was registered into the 99.step three % out-of days you to definitely gender is reported.

Table 2

The latest twelve-day cumulative incidence out of an initial HPV issues shortly after very first sex are 37.dos percent (95 % rely on interval, twenty seven.dos in order to 49.cuatro percent). All in all, 126 incident type-certain infection had been known into the forty female after they first got gender ( Desk 2 ). Incident infection have been identified within the about three lady in advance of it reported having intercourse for the first time, including one to confident to have HPV form of 51, that getting HPV sorts of 6, plus one to own HPV Spanish Sites dating apps designs forty, 61, and you can 66. The new twenty four-month cumulative incidence out of cervical squamous intraepithelial lesions is fifteen.0 per cent (95 per cent believe interval, 8.step three to 26.2 %).